Development of a diagnostic test for ME/CFS using Raman microscopy to analyse peripheral blood mononuclear cells (PMBC) and plasma
Summary of results so far (February 2019): Building on our initial data suggesting Raman microscopy of plasma blood mononuclear cells (PBMC) had potential as a diagnostic test in ME/CFS (Xu et al., 2019) we have looked at a further 41 subjects with ME/CFS (mild, moderate and severe), healthy controls and Multiple Sclerosis patients from the UK Biobank cohort. Our preliminary results using a combination of machine learning analysis of PBMC Raman spectra and the Zegami platform for data visualisation showed an extremely exciting separation of the 3 groups (see below), suggesting something is very different between the cells in the 3 groups.
Validation trial of our preliminary results
We now plan to continue this work by looking at a further 200 plasma blood mononuclear cells (PBMC) samples we have available in Oxford.
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