We are currently adopting various approaches toward subgrouping patients. One approach is metabolic profile-led subgrouping and the other is informed by a range of parameters that are captured from the Task Force Monitor^TM,  through our collaboration with the Zalewski Group (Torun, Poland) which provides in-depth profiling of autonomic nervous system function. Using biochemistry-led subgrouping we are finding one subgroup has a more marked metabolic dysregulation independent of fatigue severity.

Pictured below is a heat map based on the top 75 most statistically significant metabolites - it can be observed a subgroup of patients that are relatively similar to healthy controls for many metabolites.